Article
Genome-wide association reveals that common genetic variation in the kallikrein-kinin system is associated with serum L-arginine levels.
Thrombosis and haemostasis - 30 Nov 2016
Zhang Weihua, Jernerén Fredrik, Lehne Benjamin C, Chen Ming-Huei, Luben Robert N, Johnston Carole, Elshorbagy Amany, Eppinga Ruben N, Scott William R, Adeyeye Elizabeth, Scott James, Böger Rainer H, Khaw Kay-Tee, van der Harst Pim, Wareham Nicholas J, Vasan Ramachandran S, Chambers John C, Refsum Helga, Kooner Jaspal S
Abstract excerpt
L-arginine is the essential precursor of nitric oxide, and is involved in multiple key physiological processes, including vascular and immune function. The genetic regulation of blood L-arginine levels is largely unknown. We performed a genome-wide association study (GWAS) to identify genetic factors determining serum L-arginine levels, amongst 901 Europeans and 1,394 Indian Asians. We show that common genetic...
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