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Article

Association of functional kallikrein-1 promoter polymorphisms and acute kidney injury: a case-control and longitudinal cohort study.

Nephron. Clinical practice - 1 Jan 2012

Susantitaphong Paweena, Perianayagam Mary C, Kang Sun Woo, Zhang Wenyi, Rao Fangwen, O'Connor Daniel T, Jaber Bertrand L

Abstract excerpt

BACKGROUND: Kallikrein-1 (KLK1) is a highly conserved serine protease that is expressed in the kidney and involved in blood pressure regulation. The activity of this enzyme is diminished in acute kidney injury (AKI). METHODS: We first evaluated the potential role of functional multiallelic KLK1 promoter gene polymorphisms in a case-control study of 481 subjects (214 hospitalized patients with AKI of mixed causes...

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Identifiers

PMID: 23635481
DOI: 10.1159/000350733
PMCID: PMC3700581

Genes

KLK1

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