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Article

Both rare and common variants in PCSK9 influence plasma low-density lipoprotein cholesterol level in American Indians.

The Journal of clinical endocrinology and metabolism - 1 Feb 2015

Tsai Ching-Wei, North Kari E, Tin Adrienne, Haack Karin, Franceschini Nora, Saroja Voruganti V, Laston Sandy, Zhang Ying, Best Lyle G, MacCluer Jean W, Beaty Terri H, Navas-Acien Ana, Kao W H Linda, Howard Barbara V

Abstract excerpt

CONTEXT: Elevated LDL cholesterol (LDL-C) is an important risk factor for atherosclerosis and cardiovascular disease. Variants in the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene have been associated not only with plasma LDL-C concentration, but also with ischemic heart disease. Little is known about the genetic architecture of PCSK9 and its influence on LDL-C in American Indians. OBJECTIVE: We...

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Share to Cholesterol, LDL
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Indians, North American

Share to Polymorphism, Single Nucleotide

Share to Proprotein Convertase 9

Share to Proprotein Convertases

Share to Serine Endopeptidases

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Source

Open in PubMed Open full text

Identifiers

PMID: 25412415
DOI: 10.1210/jc.2014-3340
PMCID: PMC4318886

Genes

PCSK9
MAF

Variants

rs11591147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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