Article
Common variation in KLKB1 and essential hypertension risk: tagging-SNP haplotype analysis in a case-control study.
Human genetics - 1 May 2007
Lu Xiangfeng, Zhao Weiyan, Huang Jianfeng, Li Hongfan, Yang Wei, Wang Laiyuan, Huang Wentao, Chen Shufeng, Gu Dongfeng
Abstract excerpt
The human plasma kallikrein gene (KLKB1) encodes plasma kallikrein, a serine protease that catalyzes the release of kinins and other vasoactive peptides and may be involved in the pathogenesis of hypertension. In this study, we performed a haplotype-based study to assess the effect of common genetic variation in the KLKB1 gene on the risk of essential hypertension. Eight common single nucleotide polymorphisms...
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