Article
Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1.
Hypertension (Dallas, Tex. : 1979) - 1 Mar 2013
Verweij Niek, Mahmud Hasan, Mateo Leach Irene, de Boer Rudolf A, Brouwers Frank P, Yu Hongjuan, Asselbergs Folkert W, Struck Joachim, Bakker Stephan J L, Gansevoort Ron T, Munroe Patricia B, Hillege Hans L, van Veldhuisen Dirk J, van Gilst Wiek H, Silljé Herman H W, van der Harst Pim
Abstract excerpt
Endothelin-1 (ET-1) and adrenomedullin (ADM) are circulating vasoactive peptides involved in vascular homeostasis and endothelial function. Elevated levels of plasma ET-1 and ADM, and their biologically stable surrogates, C-terminal-pro-endothelin-1 (CT-pro-ET-1) and midregional proadrenomedullin (MR-pro-ADM), are predictors of cardiac death and heart failure. We studied the association of common genetic...
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