Article
An investigation of APOL1 risk genotypes and preterm birth in African American population cohorts.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Dec 2017
Robertson Catherine C, Gillies Christopher E, Putler Rosemary K B, Ng Derek, Reidy Kimberly J, Crawford Brendan, Sampson Matthew G
Abstract excerpt
BACKGROUND: Two genetic variants in apolipoprotein L1 (APOL1) are associated with increased risk of focal segmental glomerulosclerosis as well as other glomerular phenotypes. These risk variants are common in individuals of African ancestry but absent in other racial groups. Yet, the majority of individuals with two APOL1 risk alleles [high-risk (HR) genotype] do not have renal disease. It is critical to identify...
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