Article
Maternal variants within the apolipoprotein L1 gene are associated with preeclampsia in a South African cohort of African ancestry.
European journal of obstetrics, gynecology, and reproductive biology - 1 Mar 2020
Thakoordeen-Reddy Semone, Winkler Cheryl, Moodley Jagidesa, David Victor, Binns-Roemer Elizabeth, Ramsuran Veron, Naicker Thajasvarie
Abstract excerpt
OBJECTIVE: Preeclampsia (PE) is a complex pregnancy-specific medical disorder arising from an ischaemic placenta releasing factors causing widespread endothelial damage involving multiple organs systems, such as the renal system. Two variant alleles, termed G1 and G2, of the APOL1 gene are strongly associated with progressive renal disease and preeclampsia in the recessive or compound heterozygous state. Hence,...
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