Article
Fetal-Not Maternal-APOL1 Genotype Associated with Risk for Preeclampsia in Those with African Ancestry.
American journal of human genetics - 6 Sept 2018
Reidy Kimberly J, Hjorten Rebecca C, Simpson Claire L, Rosenberg Avi Z, Rosenblum Stacy D, Kovesdy Csaba P, Tylavsky Frances A, Myrie Joseph, Ruiz Bianca L, Haque Soulin, Mozhui Khyobeni, Nelson George W, David Victor A, Yang Xiaoping, Suzuki Masako, Jacob Jack, Reznik Sandra E, Kaskel Frederick J, Kopp Jeffrey B, Winkler Cheryl A, Davis Robert L
Abstract excerpt
Black Americans are at increased risk for preeclampsia. Genetic variants in apolipoprotein L1 (APOL1) account for much of the increased risk for kidney disease in blacks. APOL1 is expressed in human placenta and transgenic mice expressing APOL1 develop preeclampsia. We evaluated the role of APOL1 variants in human preeclampsia. We determined maternal and fetal APOL1 genotypes in black women with preeclampsia in...
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