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Article

Joint Associations of Maternal-Fetal APOL1 Genotypes and Maternal Country of Origin With Preeclampsia Risk.

American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Jun 2021

Hong Xiumei, Rosenberg Avi Z, Zhang Boyang, Binns-Roemer Elizabeth, David Victor, Lv Yiming, Hjorten Rebecca C, Reidy Kimberly J, Chen Teresa K, Wang Guoying, Ji Yuelong, Simpson Claire L, Davis Robert L, Kopp Jeffrey B, Wang Xiaobin, Winkler Cheryl A

Abstract excerpt

RATIONALE & OBJECTIVES: Preeclampsia, which disproportionately affects Black women, is a leading cause of preterm delivery and risk for future hypertension and chronic kidney disease (CKD). Apolipoprotein L1 (APOL1) kidney risk alleles, common among Black individuals, contribute substantially to CKD disparities. Given the strong link between preeclampsia and CKD, we investigated whether maternal and fetal APOL1...

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Identifiers

PMID: 33359152
DOI: 10.1053/j.ajkd.2020.10.020
PMCID: PMC8351532

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