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Article

DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism.

Scientific reports - 15 Sept 2016

Russo Giusi, Landi Rosaria, Pezone Antonio, Morano Annalisa, Zuchegna Candida, Romano Antonella, Muller Mark T, Gottesman Max E, Porcellini Antonio, Avvedimento Enrico V

Abstract excerpt

We characterize the changes in chromatin structure, DNA methylation and transcription during and after homologous DNA repair (HR). We find that HR modifies the DNA methylation pattern of the repaired segment. HR also alters local histone H3 methylation as well chromatin structure by inducing DNA-chromatin loops connecting the 5' and 3' ends of the repaired gene. During a two-week period after repair,...

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Identifiers

PMID: 27629060
DOI: 10.1038/srep33222
PMCID: PMC5024116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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