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Article

Unstable DNA repair genes shaped by their own sequence modifying phenotypes.

Journal of molecular evolution - 1 Mar 2010

Falster Daniel S, Nakken Sigve, Bergem-Ohr Marie, Rødland Einar Andreas, Breivik Jarle

Abstract excerpt

The question of whether natural selection favors genetic stability or genetic variability is a fundamental problem in evolutionary biology. Bioinformatic analyses demonstrate that selection favors genetic stability by avoiding unstable nucleotide sequences in protein encoding DNA. Yet, such unstable sequences are maintained in several DNA repair genes, thereby promoting breakdown of repair and destabilizing the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Repetitive Sequences, Nucleic Acid

Source

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Identifiers

PMID: 20213140
DOI: 10.1007/s00239-010-9328-0
PMCID: PMC2846273

Genes

MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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