Alterations in DNA methylation: a fundamental aspect of neoplasia.

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Article

Alterations in DNA methylation: a fundamental aspect of neoplasia.

Advances in cancer research - 1 Jan 1998

Baylin S B, Herman J G, Graff J R, Vertino P M, Issa J P

Abstract excerpt

Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) activity. Each component of this "methylation imbalance" may fundamentally contribute to tumor progression. The precise role of the h...

Topics

Aging
Animals
Carrier Proteins
Cell Cycle Proteins
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
DNA Methylation
Genes, Retinoblastoma
Genes, Tumor Suppressor
Humans
Mutation
Neoplasms
Transcription, Genetic
Tumor Suppressor Proteins

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Open in PubMed

Identifiers

PMID: 9338076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9338076-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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