Article
Alterations in DNA methylation: a fundamental aspect of neoplasia.
Advances in cancer research - 1 Jan 1998
Baylin S B, Herman J G, Graff J R, Vertino P M, Issa J P
Abstract excerpt
Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) activity. Each component of this "methylation imbalance" may fundamentally contribute to tumor progression. The precise role of the hypomethylation is unclear, but this change may well be involved in the widespread chromosomal alterations in tumor...
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