Non-homologous end joining induced alterations in DNA methylation: A source of permanent epigenetic change.

doi:10.18632/oncotarget.16122

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Article

Non-homologous end joining induced alterations in DNA methylation: A source of permanent epigenetic change.

Oncotarget - 20 Jun 2017

Allen Brittany, Pezone Antonio, Porcellini Antonio, Muller Mark T, Masternak Michal M

Abstract excerpt

In addition to genetic mutations, epigenetic revision plays a major role in the development and progression of cancer; specifically, inappropriate DNA methylation or demethylation of CpG residues may alter the expression of genes that promote tumorigenesis. We hypothesize that DNA repair, specifically the repair of DNA double strand breaks (DSB) by Non-Homologous End Joining (NHEJ) may play a role in this...

Topics

Alleles
Azacitidine
Cell Line, Tumor
Cell Transformation, Neoplastic
CpG Islands
DNA Breaks, Double-Stranded
DNA End-Joining Repair
DNA Methylation
Decitabine
Doxycycline
Epigenesis, Genetic
Green Fluorescent Proteins
HeLa Cells
Humans
Neoplasms

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Identifiers

PMID: 28423717
DOI: 10.18632/oncotarget.16122
PMCID: PMC5522286

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