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Article

Non-homologous end joining induced alterations in DNA methylation: A source of permanent epigenetic change.

Oncotarget - 20 Jun 2017

Allen Brittany, Pezone Antonio, Porcellini Antonio, Muller Mark T, Masternak Michal M

Abstract excerpt

In addition to genetic mutations, epigenetic revision plays a major role in the development and progression of cancer; specifically, inappropriate DNA methylation or demethylation of CpG residues may alter the expression of genes that promote tumorigenesis. We hypothesize that DNA repair, specifically the repair of DNA double strand breaks (DSB) by Non-Homologous End Joining (NHEJ) may play a role in this...

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Identifiers

PMID: 28423717
DOI: 10.18632/oncotarget.16122
PMCID: PMC5522286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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