Article
Cerebral blood flow in presymptomatic MAPT and GRN mutation carriers: A longitudinal arterial spin labeling study.
NeuroImage. Clinical - 1 Jan 2016
Dopper Elise G P, Chalos Vicky, Ghariq Eidrees, den Heijer Tom, Hafkemeijer Anne, Jiskoot Lize C, de Koning Inge, Seelaar Harro, van Minkelen Rick, van Osch Matthias J P, Rombouts Serge A R B, van Swieten John C
Abstract excerpt
OBJECTIVE: Frontotemporal dementia (FTD) is characterized by behavioral disturbances and language problems. Familial forms can be caused by genetic defects in microtubule-associated protein tau (MAPT), progranulin (GRN), and C9orf72. In light of upcoming clinical trials with potential disease-modifying agents, the development of sensitive biomarkers to evaluate such agents in the earliest stage of FTD is crucial....
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