Article
Clinical features and biomarkers of semantic variant primary progressive aphasia with MAPT mutation.
Alzheimer's research & therapy - 27 Jan 2023
Xu Jing, Xia Yanmin, Meng Meng, Liu Fang, Che Ping, Zhang Yanxin, Wang Ying, Cai Li, Qin Wen, Zhang Nan
Abstract excerpt
BACKGROUND: Semantic variant primary progressive aphasia (svPPA) is generally sporadic, with very few reports of tau pathology caused by MAPT mutations. METHODS: A 64-year-old man was diagnosed with svPPA with MAPT P301L mutation. Clinical information, cognitive and language functions, multimodal magnetic resonance imaging (MRI), blood biomarkers, fluorodeoxyglucose (FDG) imaging and tau positron emission...
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