Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer's Disease.

Cellular and molecular neurobiology - 1 Mar 2016

Hays Chelsea C, Zlatar Zvinka Z, Wierenga Christina E

Abstract excerpt

There is accumulating evidence suggesting that changes in brain perfusion are present long before the clinical symptoms of Alzheimer's disease (AD), perhaps even before amyloid-β accumulation or brain atrophy. This evidence, consistent with the vascular hypothesis of AD, implicates cerebral blood flow (CBF) in the pathogenesis of AD and suggests its utility as a biomarker of preclinical AD. The extended...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Alzheimer Disease
Share to Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebrovascular Circulation

Share to ASL gene

Share to Genetic Predisposition to Disease

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 26898552
DOI: 10.1007/s10571-015-0261-z
PMCID: PMC5278904

Genes

ASL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer's Disease.PMID 26898552Read ↗

Amyloid and Tau Pathology are Associated with Cerebral Blood Flow in a Mixed Sample of Nondemented Older Adults with and without Vascular Risk Factors for Alzheimer’s DiseaseSemantic proximity Read ↗

Use of functional magnetic resonance imaging in the early identification of Alzheimer's disease.Semantic proximity Read ↗

Cerebral blood flow in presymptomatic MAPT and GRN mutation carriers: A longitudinal arterial spin labeling study.Semantic proximity Read ↗

Critical threshold cerebral hypoperfusion causes Alzheimer's disease?Semantic proximity Read ↗

Regional hyperperfusion in cognitively normal APOE ε4 allele carriers in mid-life: analysis of ASL pilot data from the PREVENT-Dementia cohort.Semantic proximity Read ↗

Assessment of Alzheimer's disease risk with functional magnetic resonance imaging: an arterial spin labeling study.Semantic proximity Read ↗

Regional cerebral perfusion in patients with Alzheimer's disease and mild cognitive impairment: effect of APOE epsilon4 allele.Semantic proximity Read ↗

Associations between age, sex, APOE genotype, and regional vascular physiology in typically aging adults.Semantic proximity Read ↗

Early detection of Alzheimer's disease using neuroimaging.Semantic proximity Read ↗

Magnetic Resonance Imaging to Detect Early Molecular and Cellular Changes in Alzheimer's DiseaseSemantic proximity Read ↗

Aerobic exercise improves hippocampal blood flow for hypertensive<i>APOE4</i>carriersSemantic proximity Read ↗

Lower cerebral perfusion is associated with tau-PET in the entorhinal cortex across the Alzheimer's continuum.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.