Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunoseq: the identification of functionally relevant variants through targeted capture and sequencing of active regulatory regions in human immune cells.

BMC medical genomics - 13 Sept 2016

Morin Andréanne, Kwan Tony, Ge Bing, Letourneau Louis, Ban Maria, Tandre Karolina, Caron Maxime, Sandling Johanna K, Carlsson Jonas, Bourque Guillaume, Laprise Catherine, Montpetit Alexandre, Syvanen Ann-Christine, Ronnblom Lars, Sawcer Stephen J, Lathrop Mark G, Pastinen Tomi

Abstract excerpt

BACKGROUND: The observation that the genetic variants identified in genome-wide association studies (GWAS) frequently lie in non-coding regions of the genome that contain cis-regulatory elements suggests that altered gene expression underlies the development of many complex traits. In order to efficiently make a comprehensive assessment of the impact of non-coding genetic variation in immune related diseases we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Genome-Wide Association Study

Share to Molecular Sequence Annotation

Share to Quantitative Trait Loci

Share to Sequence Analysis, RNA

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 27624058
DOI: 10.1186/s12920-016-0220-7
PMCID: PMC5022205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunoseq: the identification of functionally relevant variants through targeted capture and sequencing of active regulatory regions in human immune cells.PMID 27624058Read ↗

Deciphering the genetic control of immune cell function at single-cell resolution: Disease-Specific Cis-eQTLs analysis of COVID-19.Semantic proximity Read ↗

In vivo measurement and prediction of cell-type-resolved non-coding variant effects in human immunitySemantic proximity Read ↗

Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases.Semantic proximity Read ↗

Mapping the functional impact of non-coding regulatory elements in primary T cells through single-cell CRISPR screensSemantic proximity Read ↗

Chromatin conformation dynamics during CD4+ T cell activation implicates autoimmune disease-associated genes and regulatory elementsSemantic proximity Read ↗

Single-cell RNA sequencing reveals cell-type specific <i>cis</i> -eQTLs in peripheral blood mononuclear cellsSemantic proximity Read ↗

find-tfbs: a tool to identify functional non-coding variants associated with complex human traits using open chromatin maps and phased whole-genome sequencesSemantic proximity Read ↗

Sensitive detection of chromatin-altering polymorphisms reveals autoimmune disease mechanisms.Semantic proximity Read ↗

High-resolution DNA accessibility profiles increase the discovery and interpretability of genetic associationsSemantic proximity Read ↗

Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity.Semantic proximity Read ↗

3DFAACTS-SNP: using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of type 1 diabetes (T1D) risk.Semantic proximity Read ↗

Mapping the functional impact of non-coding regulatory elements in primary T cells through single-cell CRISPR screens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.