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Article

Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity.

Nature communications - 14 Jul 2022

Gilchrist James J, Makino Seiko, Naranbhai Vivek, Sharma Piyush K, Koturan Surya, Tong Orion, Taylor Chelsea A, Watson Robert A, de Los Aires Alba Verge, Cooper Rosalin, Lau Evelyn, Danielli Sara, Hameiri-Bowen Dan, Lee Wanseon, Ng Esther, Whalley Justin, Knight Julian C, Fairfax Benjamin P

Abstract excerpt

Natural Killer cells are innate lymphocytes with central roles in immunosurveillance and are implicated in autoimmune pathogenesis. The degree to which regulatory variants affect Natural Killer cell gene expression is poorly understood. Here we perform expression quantitative trait locus mapping of negatively selected Natural Killer cells from a population of healthy Europeans (n = 245). We find a significant...

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Identifiers

PMID: 35835762
DOI: 10.1038/s41467-022-31626-4
PMCID: PMC9283523

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