Article
Impaired induction of allergic lung inflammation by Alternaria alternata mutant MAPK homologue Fus3.
Experimental lung research - 1 Nov 2013
Kim Hee-Kyoo, Baum Rachel, Lund Sean, Khorram Naseem, Yang Siwy Ling, Chung Kuang-Ren, Doherty Taylor A
Abstract excerpt
The fungal allergen Alternaria alternata is associated with development of asthma, though the mechanisms underlying the allergenicity of Alternaria are largely unknown. The aim of this study was to identify whether the MAP kinase homologue Fus3 of Alternaria contributed to allergic airway responses. Wild-type (WT) and Fus3 deficient Alternaria extracts were given intranasal to mice. Extracts from Fus3 deficient...
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