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Asthma Susceptibility Gene ORMDL3 Promotes Autophagy in Human Bronchial Epithelium.

American journal of respiratory cell and molecular biology - 1 Jun 2022

Guo Feng, Hao Yuan, Zhang Li, Croteau-Chonka Damien C, Thibault Derek, Kothari Parul, Li Lijia, Levy Bruce D, Zhou Xiaobo, Raby Benjamin A

Abstract excerpt

The genome-wide association study (GWAS)-identified asthma susceptibility risk alleles on chromosome 17q21 increase the expression of ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3) in lung tissue. Given the importance of epithelial integrity in asthma, we hypothesized that ORMDL3 directly impacted bronchial epithelial function. To determine whether and how ORMDL3 expression impacts the bronchial epithelium,...

Topics

Asthma
Autophagy
Autophagy-Related Proteins
Calcium
Epithelium
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Membrane Proteins

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Identifiers

PMID: 35353673
DOI: 10.1165/rcmb.2021-0305OC
PMCID: PMC9163638

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