Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein.

doi:10.1158/1541-7786.MCR-16-0209

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Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein.

Molecular cancer research : MCR - 1 Nov 2016

Nemec Antonia A, Bush Korie B, Towle-Weicksel Jamie B, Taylor B Frazier, Schulz Vincent, Weidhaas Joanne B, Tuck David P, Sweasy Joann B

Abstract excerpt

Repair of DNA damage is critical for maintaining the genomic integrity of cells. DNA polymerase lambda (POLL/Pol λ) is suggested to function in base excision repair (BER) and nonhomologous end-joining (NHEJ), and is likely to play a role in damage tolerance at the replication fork. Here, using next-generation sequencing, it was discovered that the POLL rs3730477 single-nucleotide polymorphism (SNP) encoding R438W...

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PMID: 27621267
DOI: 10.1158/1541-7786.MCR-16-0209
PMCID: PMC5107123

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POLL

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