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Article

The DNA2 nuclease/helicase is an estrogen-dependent gene mutated in breast and ovarian cancers.

Oncotarget - 15 Oct 2014

Strauss Carmit, Kornowski Maya, Benvenisty Avraham, Shahar Amit, Masury Hadas, Ben-Porath Ittai, Ravid Tommer, Arbel-Eden Ayelet, Goldberg Michal

Abstract excerpt

Genomic instability, a hallmark of cancer, is commonly caused by failures in the DNA damage response. Here we conducted a bioinformatical screen to reveal DNA damage response genes that are upregulated by estrogen and highly mutated in breast and ovarian cancers. This screen identified 53 estrogen-dependent cancer genes, some of which are novel. Notably, the screen retrieved 9 DNA helicases as well as 5...

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Share to Estrogens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MCF-7 Cells

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Neoplasm Transplantation

Share to Receptors, Estrogen

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Source

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Identifiers

PMID: 25238049
DOI: 10.18632/oncotarget.2414
PMCID: PMC4253442

Genes

DNA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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