Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic-Epidemiologic Evidence That Estrogens Promote Breast Cancer Development.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2018

Parl Fritz F, Crooke Philip S, Plummer W Dale, Dupont William D

Abstract excerpt

Background: Estrogens are a prime risk factor for breast cancer, yet their causal relation to tumor formation remains uncertain. A recent study of 560 breast cancers identified 82 genes with 916 point mutations as drivers in the genesis of this malignancy. Because estrogens play a major role in breast cancer development and are also known to regulate the expression of numerous genes, we hypothesize that the 82...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogen Receptor alpha

Share to Estrogens

Share to Gene Expression Regulation, Neoplastic

Share to Genomics

Share to Prognosis

Share to Tennessee

Source

Open in PubMed Open full text

Identifiers

PMID: 29789325
DOI: 10.1158/1055-9965.EPI-17-1174
PMCID: PMC6072561

Genes

ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic-Epidemiologic Evidence That Estrogens Promote Breast Cancer Development.PMID 29789325Read ↗

Estrogen receptor alpha polymorphisms and the risk of malignancies.Semantic proximity Read ↗

Molecular Characterization of ESR1 Variants in Breast CancerSemantic proximity Read ↗

Variants of estrogen-related genes and breast cancer risk in European and African American women.Semantic proximity Read ↗

Characterization of ESR1 alterations in patients with breast and gynecologic cancers.Semantic proximity Read ↗

Molecular characterization of ESR1 variants in breast cancer.Semantic proximity Read ↗

Differential association of ESR1 and ESR2 gene variants with the risk of breast cancer and associated features: A case-control study.Semantic proximity Read ↗

Diverse associations between ESR1 polymorphism and breast cancer development and progression.Semantic proximity Read ↗

Androgens and estrogens in the etiology and prevention of breast cancer.Semantic proximity Read ↗

Functional variants at the 21q22.3 locus involved in breast cancer progression identified by screening of genome-wide estrogen response elements.Semantic proximity Read ↗

The emerging role of estrogen in B cell malignanciesSemantic proximity Read ↗

Association of estrogen receptor-beta (ESR2) polymorphism and cancer risk: a meta-analysis.Semantic proximity Read ↗

ESR1 activating mutations: From structure to clinical application.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.