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Article

Is There a Role for Base Excision Repair in Estrogen/Estrogen Receptor-Driven Breast Cancers?

11 Aug 2014

Abstract excerpt

Estrogen and estrogen metabolite-induced reactive oxygen species generation can promote oxidative DNA base damage. If unrepaired, base damaging lesions could accelerate mutagenesis, leading to a "mutator phenotype" characterized by aggressive behavior in estrogen-estrogen receptor (ER)-driven breast cancer. To test this hypothesis, we investigated 1406 ER(+) early-stage breast cancers with 20 years' long-term...

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PMID: 25111287
DOI: 10.1089/ars.2014.6077

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