Article
Functional variants at the 21q22.3 locus involved in breast cancer progression identified by screening of genome-wide estrogen response elements.
Breast cancer research : BCR - 9 Oct 2014
Hsiung Chia-Ni, Chu Hou-Wei, Huang Yuan-Ling, Chou Wen-Cheng, Hu Ling-Yueh, Hsu Huan-Ming, Wu Pei-Ei, Hou Ming-Feng, Yu Jyh-Cherng, Shen Chen-Yang
Abstract excerpt
INTRODUCTION: Estrogen forms a complex with the estrogen receptor (ER) that binds to estrogen response elements (EREs) in the regulatory region of estrogen-responsive genes and regulates their transcription. Sequence variants in the regulatory regions have the potential to affect the transcription factor-regulatory sequence interaction, resulting in altered expression of target genes. This study explored the...
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