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Article

DNA polymerase β variant Ile260Met generates global gene expression changes related to cellular transformation.

Mutagenesis - 1 Nov 2012

Donigan Katherine A, Tuck David, Schulz Vince, Sweasy Joann B

Abstract excerpt

Maintenance of genomic stability is essential for cellular survival. The base excision repair (BER) pathway is critical for resolution of abasic sites and damaged bases, estimated to occur 20,000 times in cells daily. DNA polymerase β (Pol β) participates in BER by filling DNA gaps that result from excision of damaged bases. Approximately 30% of human tumours express Pol β variants, many of which have altered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22914675
DOI: 10.1093/mutage/ges034
PMCID: PMC3611876

Genes

PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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