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Evolution of Pseudomonas aeruginosa Antimicrobial Resistance and Fitness under Low and High Mutation Rates.

Antimicrobial agents and chemotherapy - 4 Jan 2016

Cabot Gabriel, Zamorano Laura, Moyà Bartolomé, Juan Carlos, Navas Alfonso, Blázquez Jesús, Oliver Antonio

Abstract excerpt

Pseudomonas aeruginosa, a major cause of nosocomial and chronic infections, is considered a paradigm of antimicrobial resistance development. However, the evolutionary trajectories of antimicrobial resistance and the impact of mutator phenotypes remain mostly unexplored. Therefore, whole-genome sequencing (WGS) was performed in lineages of wild-type and mutator (ΔmutS) strains exposed to increasing concentrations...

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Identifiers

PMID: 26729493
DOI: 10.1128/AAC.02676-15
PMCID: PMC4775977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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