Polymorphisms in a bacterial signalling pathway alter evolutionary routes of antibiotic resistance in Escherichia coli.

doi:10.1371/journal.pbio.3003977

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Article

Polymorphisms in a bacterial signalling pathway alter evolutionary routes of antibiotic resistance in Escherichia coli.

PLoS biology - 1 Aug 2026

Yelpure Chetna, Chinnaraj Saillesh, Topiwala Kush, Phadke Jay, Matange Nishad

Abstract excerpt

Antibiotic resistance in bacteria frequently evolves due to mutations in drug-target or detoxifying genes. Pre-existing polymorphisms in these genes are likely to influence the evolvability of drug resistance. However, the role of polymorphisms in driving resistance evolution and the underlying molecular mechanisms are poorly understood. Here, we demonstrate that polymorphisms in a signalling pathway impact the...

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Topics

Escherichia coli
Signal Transduction
Escherichia coli Proteins
Tetrahydrofolate Dehydrogenase
Trimethoprim
Evolution, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Genetic

Mutation

Drug Resistance, Bacterial

Gene Expression Regulation, Bacterial

Anti-Bacterial Agents

Trimethoprim Resistance

Epistasis, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 42647535
DOI: 10.1371/journal.pbio.3003977
PMCID: PMC13529223

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DHFR

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