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Polarized Lung Inflammation and Tie2/Angiopoietin-Mediated Endothelial Dysfunction during Severe <i>Orientia tsutsugamushi</i> Infection

2019-08-02

Abstract excerpt

Orientia tsutsugamushi infection can cause acute lung injury and high mortality in humans; however, the underlying mechanisms are unclear. Here, we tested a hypothesis that dysregulated pulmonary inflammation and Tie2-mediated endothelial malfunction contribute to lung damage. Using a murine model of lethal O. tsutsugamushi infection, we demonstrated pathological characteristics of vascular activation and tissue...

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Literature Corpus work
ea5955e2-88bb-58a4-b4fd-4e2871149c25
DOI
10.1101/723387
Open publication

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