Article

Mitogen-activated protein kinases and tumor necrosis factor alpha responses of macrophages infected with Orientia tsutsugamushi

2009-12-01

Abstract excerpt

Orientia tsutsugamushi, an obligatory intracellular bacterium, is the causative agent of scrub typhus. The disease is histopathologically characterized by inflammatory manifestations, indicating that orientiae induce mechanisms that amplify the inflammatory response. Here we investigated the transcriptional response of tumor necrosis factor alpha (TNF-α) gene and the host cell responses of nuclear factor-kappa B (...

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Literature Corpus work: e0159dcb-0075-5918-b877-f57e0ef30ffa
DOI: 10.1007/s11274-009-0120-5

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