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Orientia Tsutsugamushi Infection Stimulates Syk-Dependent Responses and Innate Cytosolic Defenses in Macrophages

2022-11-17

Abstract excerpt

Orientia tsutsugamushi is an obligately intracellular bacterium and the etiological agent of scrub typhus. Human studies and animal models of scrub typhus have shown robust type 1-skewed proinflammatory responses during severe infection. Macrophages (Mφ) play a critical role in initiating such responses, yet mechanisms of innate recognition for O. tsutsugamushi remain unclear. In this study, we investigated wh...

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Literature Corpus work
ac2419d6-619f-56f4-9839-f2f8918d4fe9
DOI
10.20944/preprints202211.0331.v1
Open publication

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Orientia Tsutsugamushi Infection Stimulates Syk-Dependent Responses and Innate Cytosolic Defenses in MacrophagesDOI 10.20944/preprints202211.0331.v1
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