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Article

Single-nucleotide polymorphisms in Toll-like receptor (TLR)-2, TLR4 and heat shock protein 70 genes and susceptibility to scrub typhus.

Journal of human genetics - 1 Nov 2013

Janardhanan Jeshina, Joseph Martin Sherry, Astrup Elisabeth, Veeramanikandan R, Aukrust Pål, Abraham Ooriapadickal C, Varghese George M

Abstract excerpt

Scrub typhus is a highly prevalent bacterial infection in India and South Asia that is caused by Orientia tsutsugamushi. The innate immune response to infections is modulated by Toll-like receptors (TLRs) and heat shock proteins (HSPs). This study was done to assess the prevalence and possible association of TLR and HSP polymorphisms in scrub typhus. TLR4 Asp299Gly, TLR4 Thr399Ile, TLR2 Arg753Gln and HSP70-2...

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Source

Identifiers

PMID: 23985798
DOI: 10.1038/jhg.2013.89

Genes

TLR4
TLR2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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