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Article

Identification of an elaborate complex mediating postsynaptic inhibition.

Science (New York, N.Y.) - 9 Sept 2016

Uezu Akiyoshi, Kanak Daniel J, Bradshaw Tyler W A, Soderblom Erik J, Catavero Christina M, Burette Alain C, Weinberg Richard J, Soderling Scott H

Abstract excerpt

Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. The composition of the inhibitory postsynapse and the mechanistic basis of its regulation, however, remain poorly understood. We used an in vivo chemico-genetic proximity-labeling approach to discover inhibitory postsynaptic proteins. Quantitative mass spectrometry not only recapitulated known inhibitory postsynaptic proteins but...

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Identifiers

PMID: 27609886
DOI: 10.1126/science.aag0821
PMCID: PMC5432043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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