Article
Postsynaptic PDLIM5/Enigma Homolog binds SPAR and causes dendritic spine shrinkage.
Molecular and cellular neurosciences - 1 Feb 2010
Herrick Scott, Evers Danielle M, Lee Ji-Yun, Udagawa Noriko, Pak Daniel T S
Abstract excerpt
Dendritic spine morphology is thought to play important roles in synaptic development and plasticity, and morphological derangements in spines are correlated with several neurological disorders. Here, we identified an interaction between Spine-Associated RapGAP (SPAR), a postsynaptic protein that reorganizes actin cytoskeleton and drives dendritic spine head growth, and PDLIM5/Enigma Homolog (ENH), a PDZ-LIM...
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