Article
CNTNAP2 stabilizes interneuron dendritic arbors through CASK.
Molecular psychiatry - 1 Sept 2018
Gao Ruoqi, Piguel Nicolas H, Melendez-Zaidi Alexandria E, Martin-de-Saavedra Maria Dolores, Yoon Sehyoun, Forrest Marc P, Myczek Kristoffer, Zhang Gefei, Russell Theron A, Csernansky John G, Surmeier D James, Penzes Peter
Abstract excerpt
Contactin associated protein-like 2 (CNTNAP2) has emerged as a prominent susceptibility gene implicated in multiple complex neurodevelopmental disorders, including autism spectrum disorders (ASD), intellectual disability (ID), and schizophrenia (SCZ). The presence of seizure comorbidity in many of these cases, as well as inhibitory neuron dysfunction in Cntnap2 knockout (KO) mice, suggests CNTNAP2 may be crucial...
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