Article

Network Topology reveals disrupted AMPA receptor stabilization leads to an impaired LTD in epileptic synapses

2026-08-15

Abstract excerpt

Cognitive comorbidities in epilepsy patients may be the result of synaptic alterations and impaired synaptic signalling. Electrophysiological evidence demonstrates that epileptic synapses undergo a GluN2B-dependent metaplastic shift, where a low-frequency stimulation protocol unexpectedly induced long-term potentiation (LTP) rather than long-term depression (LTD). However, the downstream postsynaptic structural ca...

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Literature Corpus work: 128ac0fd-29b0-5799-a5ec-c31cc1dc72fa
DOI: 10.64898/2026.08.10.743452

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