Article

Complex regulation of Gephyrin splicing is a determinant of inhibitory postsynaptic diversity

2021-12-16

Abstract excerpt

<title>Abstract</title> <p>Gephyrin (GPHN) regulates the clustering of postsynaptic components at inhibitory synapses and is involved in pathophysiology of neuropsychiatric disorders. Here, we uncover an extensive diversity of GPHN transcripts that are tightly controlled by splicing during mouse and human brain development. Proteomic analysis reveals at least a hundred isoforms of GPHN incorporated at inhibitory...

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Literature Corpus work: 5ababa0f-efcf-5544-9a8b-7761c09841e9
DOI: 10.21203/rs.3.rs-1111489/v1

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