Article
Connecting the Sequence-Space of Bacterial Signaling Proteins to Phenotypes Using Coevolutionary Landscapes.
Molecular biology and evolution - 1 Dec 2016
Cheng R R, Nordesjö O, Hayes R L, Levine H, Flores S C, Onuchic J N, Morcos F
Abstract excerpt
Two-component signaling (TCS) is the primary means by which bacteria sense and respond to the environment. TCS involves two partner proteins working in tandem, which interact to perform cellular functions whereas limiting interactions with non-partners (i.e., cross-talk). We construct a Potts model for TCS that can quantitatively predict how mutating amino acid identities affect the interaction between TCS...
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