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Article

The architecture of a prototypical bacterial signaling circuit enables a single point mutation to confer novel network properties.

PLoS genetics - 1 Jan 2013

Ram Sri, Goulian Mark

Abstract excerpt

Even a single mutation can cause a marked change in a protein's properties. When the mutant protein functions within a network, complex phenotypes may emerge that are not intrinsic properties of the protein itself. Network architectures that enable such dramatic changes in function from a few mut...

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Identifiers

PMID: 23990799
DOI: 10.1371/journal.pgen.1003706
PMCID: PMC3750022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-23990799-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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