Article
In vivo functional phenotypes from a computational epistatic model of evolution.
Proceedings of the National Academy of Sciences of the United States of America - 6 Feb 2024
Alvarez Sophia, Nartey Charisse M, Mercado Nicholas, de la Paz Jose Alberto, Huseinbegovic Tea, Morcos Faruck
Abstract excerpt
Computational models of evolution are valuable for understanding the dynamics of sequence variation, to infer phylogenetic relationships or potential evolutionary pathways and for biomedical and industrial applications. Despite these benefits, few have validated their propensities to generate outputs with in vivo functionality, which would enhance their value as accurate and interpretable evolutionary algorithms....
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