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Article

Evolving a robust signal transduction pathway from weak cross-talk.

Molecular systems biology - 21 Dec 2010

Siryaporn Albert, Perchuk Barrett S, Laub Michael T, Goulian Mark

Abstract excerpt

We have evolved a robust two-component signal transduction pathway from a sensor kinase (SK) and non-partner response regulator (RR) that show weak cross-talk in vitro and no detectable cross-talk in vivo in wild-type strains. The SK, CpxA, is bifunctional, with both kinase and phosphatase activities for its partner RR. We show that by combining a small number of mutations in CpxA that individually increase...

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Identifiers

PMID: 21179024
DOI: 10.1038/msb.2010.105
PMCID: PMC3018164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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