Toward rationally redesigning bacterial two-component signaling systems using coevolutionary information.

doi:10.1073/pnas.1323734111

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Toward rationally redesigning bacterial two-component signaling systems using coevolutionary information.

Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2014

Cheng Ryan R, Morcos Faruck, Levine Herbert, Onuchic José N

Abstract excerpt

A challenge in molecular biology is to distinguish the key subset of residues that allow two-component signaling (TCS) proteins to recognize their correct signaling partner such that they can transiently bind and transfer signal, i.e., phosphoryl group. Detailed knowledge of this information would allow one to search sequence space for mutations that can be used to systematically tune the signal transmission...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Evolution, Molecular
Share to Genome, Bacterial
Share to Histidine Kinase
Share to Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis

Share to Phosphorylation

Share to Protein Kinases

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 24449878
DOI: 10.1073/pnas.1323734111
PMCID: PMC3918776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.