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Article

Atomic structure of an archaeal GAN suggests its dual roles as an exonuclease in DNA repair and a CMG component in DNA replication.

Nucleic acids research - 2 Nov 2016

Oyama Takuji, Ishino Sonoko, Shirai Tsuyoshi, Yamagami Takeshi, Nagata Mariko, Ogino Hiromi, Kusunoki Masami, Ishino Yoshizumi

Abstract excerpt

In eukaryotic DNA replication initiation, hexameric MCM (mini-chromosome maintenance) unwinds the template double-stranded DNA to form the replication fork. MCM is activated by two proteins, Cdc45 and GINS, which constitute the 'CMG' unwindosome complex together with the MCM core. The archaeal DNA replication system is quite similar to that of eukaryotes, but only limited knowledge about the DNA unwinding...

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Identifiers

PMID: 27599844
DOI: 10.1093/nar/gkw789
PMCID: PMC5100581

Genes

GAN
DHH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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