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Article

Unique subunit packing in mycobacterial nanoRNase leads to alternate substrate recognitions in DHH phosphodiesterases.

Nucleic acids research - 1 Jul 2014

Srivastav Rajpal, Kumar Dilip, Grover Amit, Singh Ajit, Manjasetty Babu A, Sharma Rakesh, Taneja Bhupesh

Abstract excerpt

DHH superfamily includes RecJ, nanoRNases (NrnA), cyclic nucleotide phosphodiesterases and pyrophosphatases. In this study, we have carried out in vitro and in vivo investigations on the bifunctional NrnA-homolog from Mycobacterium smegmatis, MSMEG_2630. The crystal structure of MSMEG_2630 was determined to 2.2-Å resolution and reveals a dimer consisting of two identical subunits with each subunit folding into an...

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Identifiers

PMID: 24878921
DOI: 10.1093/nar/gku425
PMCID: PMC4081065

Genes

DHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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