A Promoter Variant Within the Aryl Hydrocarbon Receptor Gene Is Associated with an Epithelial Barrier Defect in Smokers with Crohn's Disease.

doi:10.1097/MIB.0000000000000910

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A Promoter Variant Within the Aryl Hydrocarbon Receptor Gene Is Associated with an Epithelial Barrier Defect in Smokers with Crohn's Disease.

Inflammatory bowel diseases - 1 Oct 2016

Prager Matthias, Büttner Janine, Grunert Philip, Ellinghaus David, Büning Carsten

Abstract excerpt

BACKGROUND: Smoking worsens Crohn's disease (CD). The aryl hydrocarbon receptor (AhR) is a transcription factor that mediates the toxicity of dioxinlike chemicals. We hypothesized that AHR variants and smoking influence CD. METHODS: Exon-intron boundaries and coding and promoter regions of AHR gene were sequenced (28 patients with inflammatory bowel disease; 4 healthy controls). Two identified variants (rs7796976...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colon

Share to Crohn Disease

Share to Intestinal Mucosa

Share to Permeability

Share to Real-Time Polymerase Chain Reaction

Share to Receptors, Aryl Hydrocarbon

Share to Sequence Analysis

Source

Open in PubMed

Identifiers

PMID: 27598741
DOI: 10.1097/MIB.0000000000000910

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Promoter Variant Within the Aryl Hydrocarbon Receptor Gene Is Associated with an Epithelial Barrier Defect in Smokers with Crohn's Disease.PMID 27598741Read ↗

IBD risk locus rs1077773 is a pharmacogenomic eQTL for aryl hydrocarbon receptor activity and modulates immune cell functionSemantic proximity Read ↗

IBD risk locus rs1077773 enhances aryl hydrocarbon receptor activity and modulates immune cell function in vitro.Semantic proximity Read ↗

[Association of Crohn's disease with aryl hydrocarbon receptor gene polymorphisms and haplotypes].Semantic proximity Read ↗

Role of the xenobiotic receptor in inflammatory bowel disease.Semantic proximity Read ↗

A family with ulcerative colitis maps to 7p21.1 and comprises a region with regulatory activity for the aryl hydrocarbon receptor gene.Semantic proximity Read ↗

Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease.Semantic proximity Read ↗

Genetic Factors Interact With Tobacco Smoke to Modify Risk for Inflammatory Bowel Disease in Humans and Mice.Semantic proximity Read ↗

Decreased Aryl Hydrocarbon Receptor Gene Expression and Polymorphic Variants Association with Increase COPD Risk.Semantic proximity Read ↗

Smoking Interacts With CHRNA5, a Nicotinic Acetylcholine Receptor Subunit Gene, to Influence the Risk of IBD-Related Surgery.Semantic proximity Read ↗

The role of fatty acid hydrolase gene variants in inflammatory bowel disease.Semantic proximity Read ↗

Smoking behaviour modifies IL23r-associated disease risk in patients with Crohn's disease.Semantic proximity Read ↗

Polymorphism in the retinoic acid metabolizing enzyme CYP26B1 and the development of Crohn's Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.