Article

IBD risk locus rs1077773 is a pharmacogenomic eQTL for aryl hydrocarbon receptor activity and modulates immune cell function

2025-09-29

Abstract excerpt

<h4>Introduction</h4> The inflammatory bowel diseases (IBD) Crohn’s disease (CD) and ulcerative colitis (UC) are disorders that cause chronic inflammation of the gastrointestinal tract. Both genetic and environmental factors contribute to the pathogenesis of IBD. There are currently >200 known genetic susceptibility loci for the development of IBD. The physiological impact of the majority of these loci remain a g...

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Literature Corpus work: b6568a65-f28d-5f87-b5f2-7d36cbf73995
DOI: 10.1101/2025.09.26.678301

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