Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphism in the retinoic acid metabolizing enzyme CYP26B1 and the development of Crohn's Disease.

PloS one - 1 Jan 2013

Fransén Karin, Franzén Petra, Magnuson Anders, Elmabsout Ali Ateia, Nyhlin Nils, Wickbom Anna, Curman Bengt, Törkvist Leif, D'Amato Mauro, Bohr Johan, Tysk Curt, Sirsjö Allan, Halfvarson Jonas

Abstract excerpt

Several studies suggest that Vitamin A may be involved in the pathogenesis of inflammatory bowel disease (IBD), but the mechanism is still unknown. Cytochrome P450 26 B1 (CYP26B1) is involved in the degradation of retinoic acid and the polymorphism rs2241057 has an elevated catabolic function of retinoic acid, why we hypothesized that the rs2241057 polymorphism may affect the risk of Crohn's disease (CD) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alleles
Share to Case-Control Studies
Share to Colitis, Ulcerative
Share to Crohn Disease
Share to Cytochrome P-450 Enzyme System
Share to Gene Frequency
Share to Genetic Association Studies
Share to Tretinoin

Source

Open in PubMed Open full text

Identifiers

PMID: 23977348
DOI: 10.1371/journal.pone.0072739
PMCID: PMC3747106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphism in the retinoic acid metabolizing enzyme CYP26B1 and the development of Crohn's Disease.PMID 23977348Read ↗

MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients.Semantic proximity Read ↗

Associations between vitamin D receptor polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: a meta-analysis.Semantic proximity Read ↗

A functional polymorphism in UGT1A1 related to hyperbilirubinemia is associated with a decreased risk for Crohn's disease.Semantic proximity Read ↗

The Role of Vitamin D and Vitamin D Receptor Gene Polymorphisms in the Course of Inflammatory Bowel Disease in Children.Semantic proximity Read ↗

Analysis of IL12B gene variants in inflammatory bowel disease.Semantic proximity Read ↗

Genetic analysis of MDR1 and inflammatory bowel disease reveals protective effect of heterozygous variants for ulcerative colitis.Semantic proximity Read ↗

Association of ABCB1 polymorphisms and ulcerative colitis susceptibility.Semantic proximity Read ↗

Association of vitamin D receptor gene polymorphisms in Iranian patients with inflammatory bowel disease.Semantic proximity Read ↗

CYP27B1 Gene Polymorphism rs10877012 in Patients Diagnosed with Colorectal Cancer.Semantic proximity Read ↗

Associations between ABCB1/MDR1 gene polymorphisms and Crohn's disease: a gene-wide study in a pediatric population.Semantic proximity Read ↗

Association study of MICA-TM polymorphism with inflammatory bowel disease in the South Tunisian population.Semantic proximity Read ↗

Analysis of the influence of two CD24 genetic variants in Crohn's disease and ulcerative colitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.