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Article

A family with ulcerative colitis maps to 7p21.1 and comprises a region with regulatory activity for the aryl hydrocarbon receptor gene.

European journal of human genetics : EJHG - 1 Dec 2023

Eiberg Hans, Olsson Josephine B, Bak Mads, Bang-Berthelsen Claus Heiner, Troelsen Jesper T, Hansen Lars

Abstract excerpt

We have mapped a locus on chromosome 7p22.3-7p15.3 spanning a 22.4 Mb region for ulcerative colitis (UC) by whole genome linkage analyses of a large Danish family. The family represent three generations with UC segregating as an autosomal dominant trait with variable expressivity. The whole-genome scan resulted in a logarithm of odds score (LOD score) of Z = 3.31, and a whole genome sequencing (WGS) of two...

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Share to Colitis, Ulcerative
Share to Genetic Linkage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Receptors, Aryl Hydrocarbon

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Identifiers

PMID: 36732664
DOI: 10.1038/s41431-023-01298-9
PMCID: PMC10689720

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