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Article

IBD risk locus rs1077773 enhances aryl hydrocarbon receptor activity and modulates immune cell function in vitro.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 10 Apr 2026

King Ashley C, Seiler Kristen, Swanson Kerry, Ciorba Matthew A, Alvarado David M

Abstract excerpt

INTRODUCTION: The inflammatory bowel diseases (IBD) Crohn's disease (CD) and ulcerative colitis (UC) are disorders that cause chronic inflammation of the gastrointestinal tract. Both genetic and environmental factors contribute to the pathogenesis of IBD. There are currently >200 known genetic susceptibility loci for the development of IBD. The physiological impact of the majority of these loci remain a gap in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41961102
DOI: 10.1007/s00011-026-02236-3
PMCID: PMC13068725

Genes

AHR
CYP1A1
CYP1B1
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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