Article
The role of fatty acid hydrolase gene variants in inflammatory bowel disease.
Alimentary pharmacology & therapeutics - 1 Mar 2009
Storr M, Emmerdinger D, Diegelmann J, Yüce B, Pfennig S, Ochsenkühn T, Göke B, Lohse P, Brand S
Abstract excerpt
BACKGROUND: Recent studies suggest a role for the endocannabinoid system, including fatty acid amide hydrolase (FAAH), in intestinal inflammation. AIM: To analyse FAAH expression and the FAAH 385 C/A (p.Pro129Thr; rs324420) single nucleotide polymorphism (SNP) in-patients with Crohn's disease (CD) and ulcerative colitis (UC). PATIENTS AND METHODS: Genomic DNA from 1008 individuals (CD: n = 435; UC: n = 167;...
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